Polyol pathway has been implicated as a major contributor in the pathogenesis of diabetic cataract along with chronic hyperglycemia as the root cause. In the present study, we have investigated the novel effect 2 4 thiazolidinedione derivatives that have potential to inhibit the aldose reductase enzyme and to act as a ligand of PPAR-gamma against galactose-induced and streptozotocin (STZ)-induced diabetic cataract in rats.
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